Antinociceptive activities of the methanolic extract of Prosopis africana (Guill and Perr) Taub. fruits in vivo

Prosopis africana (Guill and Perr) Taub fruit methanolic extract was tested for its antinociceptive properties. 4.2% w/w dry yield obtained after 48 hours of 80% methanol at room temperature during cold maceration. occasional shake every two hours. It had a golden brown color, sticky odorous, foamed as it dissolved in distilled water. In mice, the did not exhibit any acute hazardous effects studied dosage range (250-2000 mg/kg, i.p.). The maximum dose 2000 mg/kg administered intravenously well tolerated with just brief indications drowsiness that persisted three With potency equivalent to 2% lignocaine hydrochloride, desensitization guinea pig skin demonstrated intradermal injecting 3 mg/ml concentration. hydrochloride computed slopes 34.9 10.6, respectively. contrast previous dosages (500 1000 mg/kg), administration intraperitoneally (100 mg/kg) 30 minutes before sodium pentobarbitone (35 i.p) significantly (p 0.05) decreased sleeping period mice. writhings/contortions caused by acetic acid were considerably dose-dependently intraperitoneal injection 0.7% (10 ml/kg) administered, doses (250, 500, administered. extract's inhibitory impact i.p.) indomethacin's effect. findings this research have validated traditional usage relief headaches, toothaches, body aches.